Scientific published articles related to CuradermBEC5 and/or its active ingredients

Selected limited number of published articles

related to Curaderm BEC5 and/or its active

ingredients

 

1985

Thorne, H.V., Clarke, G.F. and Skuce, R. (1985) The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids. Antivirus Research, 5, 335-343.

doi:10.1016/0166-3542(85)90003-8

 

1987

Cham, B.E. and Wilson, L. (1987) HPLC of glycoalkaloids from Solanum sodomaeum L. Planta Medica, 53, 59-61.

doi:10.1055/s-2006-962621

 

Cham, B.E., Gilliver, M. and Wilson, L. (1987) Antitumour effects of glycoalkaloids isolated from Solanum sodomaeum L. Planta Medica, 53, 34-36.

doi:10.1055/s-2006-962612

 

Cham, B.E. and Meares, M.M. (1987) Glycoalkaloids from Solanum sodomaeum L. are effective in the treatment of skin cancers in man. Cancer Letters, 36, 111-118.

doi:10.1016/0304-3835(87)90081-4

 

1990

Daunter, B. and Cham, B.E. (1990) Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells. Cancer Letters, 55, 209-220.

doi:10.1016/0304-3835(90)90121-D

 

Cham, B.E. and Daunter, B. (1990) Solasodine glycosides. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. Cancer Letters, 55, 221-225.

doi:10.1016/0304-3835(90)90122-E

 

1991

Cham, B.E., Daunter, B. and Evans, R. (1991) Topical treatment of malignant and premalignant skin cancers by very low concentrations of a standard mixture of solasodine glycosides. Cancer Letters, 59, 183-192.

doi:10.1016/0304-3835(91)90140-D

 

1993

Cham, B.E. (1993) Efficacy and mode of action of solasodine glycosides (BEC) on cancer cells. Proceedings of 4th Oceania Symposium, Bioconcepts Publishing, 41- 51.

 

1994

Cham, B.E. (1994) Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacific Journal of Pharmacology, 9, 113-118.

 

1996

Nakamura, T., Komori, C., Lee, Y., Hashinoto, F., Yahara, S., Nohara T. and Ejina, A. (1996) Cytotoxic activities of Solanum steroidal glycosides. Biological Biopharmaceutical Bulletin, 19, 564-566.

doi:10.1248/bpb.19.564

 

Hsu, S.H., Tsai, T.R., Lin, C.N., Yen, M.H. and Kuo, K.W. (1996) Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR1 which may lead to apoptosis. Biochemical and Biophysical Research Communication, 229, 1-5.

doi:10.1006/bbrc.1996.1748

 

Chataing, B., Concepcion, J.L., Buitrago de Cristancho, N. and Usubillaga, A. (1996) Clinical study of the effectiveness of extracts alkaloids obtained of the fruits of Solanum americanum miller on herpes simplex, herpes two zoster and genital herpes. Rev. Fac Pharmacy, Univ. Los Andes, 32, 18-25.

 

1998

Chang, L.C., Tsai, T.R., Wang, J.J., Lin, C.N. and Kuo, K.W. (1998) The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis. Biochemical and Biophysical Research Communication, 242, 21-25.

doi:10.1006/bbrc.1997.7903

 

1999

Kuo, K.W. and Lin, C.N. (1999) Pharmacological composition for treating cancer cells. US Patent No. 6214803.

 

2000

Kuo, K.W., Hsu, S.H., Li, Y.P., Lin, W.L., Liu, L.F., Chang, L.C., Lin, C.C., Lin, C.N. and Sheu, H.M. (2000) Anticancer activity evaluation of the Solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochemical Pharmacology, 60, 1865-1873.

doi:10.1016/S0006-2952(00)00506-2

 

2002

Esteves-Souza, A., Silva T.M. and Alves, C.C.F. (2002) Cytotoxic activities against Ehrlich carcinoma and human K562 leukemia of alkaloids and flavonoid from two Solanum species. Journal of Brazil Chemical Society, 13, 838- 842.

doi:10.1590/S0103-50532002000600017

 

Solbec Pty Ltd. http://www.solbec.com.au

 

2004

Lee, K.R., Kozukue, N.J., Han, S.J., Park, H., Chang, E.Y., Back, E.J., Chang J.S. and Friedman, M. (2004) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. Journal of Agricultural Food Chemistry, 52, 2832-2839.

doi:10.1021/jf030526d

 

Liu, L.F., Liang, C.H., Shiu, L.Y., Lin, W.L., Lin, C.C. and Kuo, K.W. (2004) Action of solamargine on human lung cancer cells-enhancement of the susceptibility of cancer cells to TNFs. FEBS Letters, 577, 67-74.

doi:10.1016/j.febslet.2004.09.064

 

2005

Lipscombe, R.J., Carter, S.J. and Ruane, M. (2005) Rhamnose binding protein. US Patent No. 6930171.

 

Millward, M., Powell, A., Tyson, S., Daly, P., Ferguson, R. and Carter, S. (2005) Phase I trial of coramsine (SBP002) in patients with advanced solid tumours. Journal of Clinical Oncology, 23, 3105.

 

2006

He, D.J. (2006) Structure and anticancer activity of glycoalkaloids. Master’s Thesis.

 

Ono, M., Nishimura, K.K., Suzuki, T., Fukushima, K., Igoshi, H., Yoshimitsu, H., Ikeda, T. and Nohara, T. (2006) Steroidal glycosides from the underground parts of Solanum sodomaeum. Chemical Pharmacy Bulletin, 54, 230-233.

doi:10.1248/cpb.54.230

 

Millward, M., Powell, A., Daly, P., Tyson, R., Ferguson, R. and Carter, S. (2006) Results of phase I clinical trials of coramsine in patients with advanced solid tumours. Journal of Clinical Oncology, 24, 2070.

 

2007

Shiu, L.Y., Chang, L.C., Liang, C.H., Huang, Y.S., Sheu, H.M. and Kuo, K. W. (2007) Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food Chemical Toxicology, 45, 2155-2164.

doi:10.1016/j.fct.2007.05.009

 

Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M., Kuo, K.W. (2007) Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition Research, 51, 999-1005.

doi:10.1002/mnfr.200700044

 

Cham, B.E. (2007) Review article. Solasodine rhamnosyl glycosides specificallybind cancer cell receptors and induce apoptosis and necrosis. Treatment for skin cancer and hope for internal cancers. Research Journal of Biological Sciences, 2,503-514.

doi=rjbsci.2007.503.514

 

Cham, B.E. (2007) Solasodine rhamnosyl glycosides in a cream formulation is effective for treating large and troublesome skin cancers. Research Journal of Biological Sciences, 2, 749-761.

doi=rjbsci.2007.749.761

 

2008

Cham, B.E. (2008) Cancer intralesion chemotherapy with solasodine rhamnosyl glycosides. Research Journal of Biological Science, 3(9), 1008-1017.

doi=rjbsci.2008.1008.1017

 

Punjabi, S., Cook, L.J., Kersey, P., Marks R. and Cerio, R. (2008) Solasodine glycoalkaloids: A novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicentre study. International Journal of Dermatology, 47, 78-82.

doi:10.1111/j.1365-4632.2007.03363.x

 

2009

Shiu, L.Y., Liang, C.H., Chang, L.C., Sheu, H.M., Tsai, E.M. and Kuo, K.W. (2009) Solamargine induces apoptosis and enhances susceptibility to trastazumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu. Bioscience Reports, 29, 35-45.

doi:10.1042/BSR20080028

 

2010

Sun, L., Zhao, Y., Li, X., Yuan, H., Cheng, A. and Lou, H. (2010) A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells. Toxicology in Vitro, 24, 1504-1511.

doi:10.1016/j.tiv.2010.07.013

 

Sun, L., Zhao, Y., Yuan, H., Li, X., Cheng A. and Lou, H. (2010) Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells. Cancer Chemotherapy Pharmacology, 65, 1125-1130.

doi: 10.1007/s00280-010-1387-9

 

2011

Li, X., Zhao, Y., Wu, W.K.K., Liu, S., Cui, M. and Lou, H. (2011) Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U20S cells. Life Science, 88, 314-321.

doi:10.1016/j.lfs.2010.12.006

 

Wang, Y., Gao, J., Gu, G., Li, G., Cui, C., Sun, B. and Lou, H. (2011) In situ RBLreceptor visualization and its mediated anticancer activity for solasodinerhamnosides. Chemistry Biochemistry, 12, 2418-2420.

doi:10.1002/cbic.201100551

 

Li, X., Zhao, Y., Ji, M., Liu, S.S., Cui, M. and Lou, H.X. (2011) Induction of actin disruption and downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition Research, 51(8), 999-1005.

doi: 10.1002/mnfr.200700044

 

Cham, B.E. (2011) Topical solasodine rhamnosyl glycosides derived from the eggplant treats large skin cancers: Two case reports. International Journal of Clinical Medicine, 2, 473-477.

doi:10.4236/ijcm.2011.24080

 

Tavares, D.C., Munari, C.C., Araujo, M.G., Beltrame, M.C., Furtado, M.H., Goncalves, C.C., Tiossi, R.F., Bastos, J.K., Cunha, W.R. and Veneziani, R.C. (2011) Antimutagenic potential of Solanum lycocarpum against induction of chromosomal aberrations in V79 and micronuclei in mice by doxorubicin. Planta Medica, 77, 1489- 1494.

doi:10.1055/s-0030-1270886

 

Tang, Z., Zhang, Y., Li, N., Xu, L., Zhao, B., Xiao, W., Wang, Z. and Bi, Y. (2011) Extraction, purification technology and antineoplastic effects of solamargine. Zhongguo Zhong Yao Za Zhi, Journal of Chinese Material Medicine, 36(16), 2192-2195.

 

Wu, C.H., Liang, C.H., Shiu, L.Y., Chang, L.C., Lin, T.S., Lan, C.E.R., Tsai, J.C., Wong, T.W., Wei, K.J., Lin, T.K., Chang, N.S. and Sheu, H.M. (2011) Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway. Journal of Dermatological Science, 63, 83-92.

doi: 10.1016/j.jdermsci.2011.04.003

 

Chase, T.R. (2011) Curaderm BEC5 for skin cancers, is it? An overview. Journal of Cancer Therapy, 2, 728-745.

doi:10.4236/jct.2011.25099

 

Goldberg, L.H., Landau, J.M., Moody, M.N. and VergilisKalner, I.J. (2011) Treatment of Bowen’s disease on the penis with low concentration of a standard mixture of solasodine glycosides and liquid nitrogen. Dermatologic Surgery, 37, 858-861.

doi:10.1111/j.1524-4725.2011.02014.x

 

2012

Cham, B.E. and Chase, T.R. (2012) Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer? Planta Medica, 78, 349-353.

doi:10.1055/s-0031-1298149

 

Ding, X., Zhu, F.S., Li, M. and Gao, S.G. (2012) Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. Journal of Ethnopharmacology, 39, 599-604.

doi:10.1016/j.jep.2011.11.058

 

Cham, B.E. (2012) Intralesion and Curaderm BEC5 topical combination therapies of solasodine rhamnosyl glycosides derived from the eggplant or devil’s apple result in a rapid removal of large skin cancers. Methods of treatment compared. International Journal of Clinical Medicine, 3, 115-124.

doi: 10.4236/ijcm.2012.32024

 

2013

Cham, B.E. (2013) Inspired by nature, proven by science. The new generation cancer treatment that causes cancer cells to commit suicide. Published.

www.curadermbec5.com

 

Cham, B.E. (2013) Solasodine glycosides: A topical therapy for actinic keratosis.A single-blind, randomized, placebo-controlled, parallel group study with CuradermBEC5

doi: 10.4236/jct.2013.42076

 

Cham, B.E. (2013) Topical CuradermBEC5 Skin Cancer: A Review of Clinical Outcomes. International Journal of Clinical Medicine, 4(5), 233-238.

doi: 10.4236/ijcm.2013.45041

 

Cham, B.E. (2013) Drug Therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents. Modern Chemotherapy, 2(2), 33-49.

doi: 10.4236/mc.2013.22005

 

2014

Cham, B.E. (2014) A Review of Solasodine Rhamnosides Therapy for Cancers on the Penis. British Journal of Medicine & Medical Research, 4(2), 621-631.

doi: 10.9734/BJMMR/2014/4677

 

To date there have been over 40,000

citations/downloads on Curaderm articles.

 

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