Scientific published articles related to CuradermBEC5 and/or its active ingredients

Selected limited number of published articles

related to Curaderm BEC5 and/or its active




Thorne, H.V., Clarke, G.F. and Skuce, R. (1985) The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids. Antivirus Research, 5, 335-343.




Cham, B.E. and Wilson, L. (1987) HPLC of glycoalkaloids from Solanum sodomaeum L. Planta Medica, 53, 59-61.



Cham, B.E., Gilliver, M. and Wilson, L. (1987) Antitumour effects of glycoalkaloids isolated from Solanum sodomaeum L. Planta Medica, 53, 34-36.



Cham, B.E. and Meares, M.M. (1987) Glycoalkaloids from Solanum sodomaeum L. are effective in the treatment of skin cancers in man. Cancer Letters, 36, 111-118.




Daunter, B. and Cham, B.E. (1990) Solasodine glycosides. In vitro preferential cytotoxicity for human cancer cells. Cancer Letters, 55, 209-220.



Cham, B.E. and Daunter, B. (1990) Solasodine glycosides. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. Cancer Letters, 55, 221-225.




Cham, B.E., Daunter, B. and Evans, R. (1991) Topical treatment of malignant and premalignant skin cancers by very low concentrations of a standard mixture of solasodine glycosides. Cancer Letters, 59, 183-192.




Cham, B.E. (1993) Efficacy and mode of action of solasodine glycosides (BEC) on cancer cells. Proceedings of 4th Oceania Symposium, Bioconcepts Publishing, 41- 51.



Cham, B.E. (1994) Solasodine glycosides as anti-cancer agents: Pre-clinical and clinical studies. Asia Pacific Journal of Pharmacology, 9, 113-118.



Nakamura, T., Komori, C., Lee, Y., Hashinoto, F., Yahara, S., Nohara T. and Ejina, A. (1996) Cytotoxic activities of Solanum steroidal glycosides. Biological Biopharmaceutical Bulletin, 19, 564-566.



Hsu, S.H., Tsai, T.R., Lin, C.N., Yen, M.H. and Kuo, K.W. (1996) Solamargine purified from Solanum incanum Chinese herb triggers gene expression of human TNFR1 which may lead to apoptosis. Biochemical and Biophysical Research Communication, 229, 1-5.



Chataing, B., Concepcion, J.L., Buitrago de Cristancho, N. and Usubillaga, A. (1996) Clinical study of the effectiveness of extracts alkaloids obtained of the fruits of Solanum americanum miller on herpes simplex, herpes two zoster and genital herpes. Rev. Fac Pharmacy, Univ. Los Andes, 32, 18-25.



Chang, L.C., Tsai, T.R., Wang, J.J., Lin, C.N. and Kuo, K.W. (1998) The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis. Biochemical and Biophysical Research Communication, 242, 21-25.




Kuo, K.W. and Lin, C.N. (1999) Pharmacological composition for treating cancer cells. US Patent No. 6214803.



Kuo, K.W., Hsu, S.H., Li, Y.P., Lin, W.L., Liu, L.F., Chang, L.C., Lin, C.C., Lin, C.N. and Sheu, H.M. (2000) Anticancer activity evaluation of the Solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells. Biochemical Pharmacology, 60, 1865-1873.




Esteves-Souza, A., Silva T.M. and Alves, C.C.F. (2002) Cytotoxic activities against Ehrlich carcinoma and human K562 leukemia of alkaloids and flavonoid from two Solanum species. Journal of Brazil Chemical Society, 13, 838- 842.



Solbec Pty Ltd.



Lee, K.R., Kozukue, N.J., Han, S.J., Park, H., Chang, E.Y., Back, E.J., Chang J.S. and Friedman, M. (2004) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. Journal of Agricultural Food Chemistry, 52, 2832-2839.



Liu, L.F., Liang, C.H., Shiu, L.Y., Lin, W.L., Lin, C.C. and Kuo, K.W. (2004) Action of solamargine on human lung cancer cells-enhancement of the susceptibility of cancer cells to TNFs. FEBS Letters, 577, 67-74.




Lipscombe, R.J., Carter, S.J. and Ruane, M. (2005) Rhamnose binding protein. US Patent No. 6930171.


Millward, M., Powell, A., Tyson, S., Daly, P., Ferguson, R. and Carter, S. (2005) Phase I trial of coramsine (SBP002) in patients with advanced solid tumours. Journal of Clinical Oncology, 23, 3105.



He, D.J. (2006) Structure and anticancer activity of glycoalkaloids. Master’s Thesis.


Ono, M., Nishimura, K.K., Suzuki, T., Fukushima, K., Igoshi, H., Yoshimitsu, H., Ikeda, T. and Nohara, T. (2006) Steroidal glycosides from the underground parts of Solanum sodomaeum. Chemical Pharmacy Bulletin, 54, 230-233.



Millward, M., Powell, A., Daly, P., Tyson, R., Ferguson, R. and Carter, S. (2006) Results of phase I clinical trials of coramsine in patients with advanced solid tumours. Journal of Clinical Oncology, 24, 2070.



Shiu, L.Y., Chang, L.C., Liang, C.H., Huang, Y.S., Sheu, H.M. and Kuo, K. W. (2007) Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin. Food Chemical Toxicology, 45, 2155-2164.



Liang, C.H., Shiu, L.Y., Chang, L.C., Sheu, H.M., Kuo, K.W. (2007) Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition Research, 51, 999-1005.



Cham, B.E. (2007) Review article. Solasodine rhamnosyl glycosides specificallybind cancer cell receptors and induce apoptosis and necrosis. Treatment for skin cancer and hope for internal cancers. Research Journal of Biological Sciences, 2,503-514.



Cham, B.E. (2007) Solasodine rhamnosyl glycosides in a cream formulation is effective for treating large and troublesome skin cancers. Research Journal of Biological Sciences, 2, 749-761.




Cham, B.E. (2008) Cancer intralesion chemotherapy with solasodine rhamnosyl glycosides. Research Journal of Biological Science, 3(9), 1008-1017.



Punjabi, S., Cook, L.J., Kersey, P., Marks R. and Cerio, R. (2008) Solasodine glycoalkaloids: A novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicentre study. International Journal of Dermatology, 47, 78-82.




Shiu, L.Y., Liang, C.H., Chang, L.C., Sheu, H.M., Tsai, E.M. and Kuo, K.W. (2009) Solamargine induces apoptosis and enhances susceptibility to trastazumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu. Bioscience Reports, 29, 35-45.




Sun, L., Zhao, Y., Li, X., Yuan, H., Cheng, A. and Lou, H. (2010) A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells. Toxicology in Vitro, 24, 1504-1511.



Sun, L., Zhao, Y., Yuan, H., Li, X., Cheng A. and Lou, H. (2010) Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells. Cancer Chemotherapy Pharmacology, 65, 1125-1130.

doi: 10.1007/s00280-010-1387-9



Li, X., Zhao, Y., Wu, W.K.K., Liu, S., Cui, M. and Lou, H. (2011) Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U20S cells. Life Science, 88, 314-321.



Wang, Y., Gao, J., Gu, G., Li, G., Cui, C., Sun, B. and Lou, H. (2011) In situ RBLreceptor visualization and its mediated anticancer activity for solasodinerhamnosides. Chemistry Biochemistry, 12, 2418-2420.



Li, X., Zhao, Y., Ji, M., Liu, S.S., Cui, M. and Lou, H.X. (2011) Induction of actin disruption and downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells. Molecular Nutrition Research, 51(8), 999-1005.

doi: 10.1002/mnfr.200700044


Cham, B.E. (2011) Topical solasodine rhamnosyl glycosides derived from the eggplant treats large skin cancers: Two case reports. International Journal of Clinical Medicine, 2, 473-477.



Tavares, D.C., Munari, C.C., Araujo, M.G., Beltrame, M.C., Furtado, M.H., Goncalves, C.C., Tiossi, R.F., Bastos, J.K., Cunha, W.R. and Veneziani, R.C. (2011) Antimutagenic potential of Solanum lycocarpum against induction of chromosomal aberrations in V79 and micronuclei in mice by doxorubicin. Planta Medica, 77, 1489- 1494.



Tang, Z., Zhang, Y., Li, N., Xu, L., Zhao, B., Xiao, W., Wang, Z. and Bi, Y. (2011) Extraction, purification technology and antineoplastic effects of solamargine. Zhongguo Zhong Yao Za Zhi, Journal of Chinese Material Medicine, 36(16), 2192-2195.


Wu, C.H., Liang, C.H., Shiu, L.Y., Chang, L.C., Lin, T.S., Lan, C.E.R., Tsai, J.C., Wong, T.W., Wei, K.J., Lin, T.K., Chang, N.S. and Sheu, H.M. (2011) Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway. Journal of Dermatological Science, 63, 83-92.

doi: 10.1016/j.jdermsci.2011.04.003


Chase, T.R. (2011) Curaderm BEC5 for skin cancers, is it? An overview. Journal of Cancer Therapy, 2, 728-745.



Goldberg, L.H., Landau, J.M., Moody, M.N. and VergilisKalner, I.J. (2011) Treatment of Bowen’s disease on the penis with low concentration of a standard mixture of solasodine glycosides and liquid nitrogen. Dermatologic Surgery, 37, 858-861.




Cham, B.E. and Chase, T.R. (2012) Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer? Planta Medica, 78, 349-353.



Ding, X., Zhu, F.S., Li, M. and Gao, S.G. (2012) Induction of apoptosis in human hepatoma SMMC-7721 cells by solamargine from Solanum nigrum L. Journal of Ethnopharmacology, 39, 599-604.



Cham, B.E. (2012) Intralesion and Curaderm BEC5 topical combination therapies of solasodine rhamnosyl glycosides derived from the eggplant or devil’s apple result in a rapid removal of large skin cancers. Methods of treatment compared. International Journal of Clinical Medicine, 3, 115-124.

doi: 10.4236/ijcm.2012.32024



Cham, B.E. (2013) Inspired by nature, proven by science. The new generation cancer treatment that causes cancer cells to commit suicide. Published.


Cham, B.E. (2013) Solasodine glycosides: A topical therapy for actinic keratosis.A single-blind, randomized, placebo-controlled, parallel group study with CuradermBEC5

doi: 10.4236/jct.2013.42076


Cham, B.E. (2013) Topical CuradermBEC5 Skin Cancer: A Review of Clinical Outcomes. International Journal of Clinical Medicine, 4(5), 233-238.

doi: 10.4236/ijcm.2013.45041


Cham, B.E. (2013) Drug Therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents. Modern Chemotherapy, 2(2), 33-49.

doi: 10.4236/mc.2013.22005



Cham, B.E. (2014) A Review of Solasodine Rhamnosides Therapy for Cancers on the Penis. British Journal of Medicine & Medical Research, 4(2), 621-631.

doi: 10.9734/BJMMR/2014/4677


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